Contact Information
Extension: 54922 | Email: bcoomber@uoguelph.ca
Areas of Interest
- Angiogenesis and Anti-angiogenic Therapy in Cancer
- Tumour Biology, Microenvironment and Mutagenesis
- Epigenetic Changes in Cancer
- Cancer Cell Survival in Suspension
Current Graduate Students
Amanda Barber, B.Sc. (Guelph)
- M.Sc. candidate
Leanne Delaney, B.Sc.H. (St. FX)
- M.Sc. candidate
Nathan Farias, B.Sc. (Guelph)
- M.Sc. candidate
Nelson Ho,
B.Sc.H. (Guelph)
Targeting energy metabolism in colorectal cancer cells.
- Ph.D. candidate
Mai Jarad, B.Sc. (Saudi Arabia)
- M.Sc. candidate
Kaya Skowronski, B.Sc. (Guelph)
Tumor microenvironment effects on DNA methytransferase expression.
- Ph.D. candidate
Una Adamcic, B.Sc. (Waterloo)
Tumor angiogenesis and the expression of Tie2 tyrosine kinase receptor in cancer.
- Ph.D. candidate - GRADUATED S'10
Elizabeth Kuczynski, B.Sc. (Guelph)
The mechanisms of VEGFR-2 heterogeneity in the tumor vasculature.
- M.Sc. candidate - GRADUATED S'10
Kristen Lacombe, B.Sc. (Guelph)
Microenvironmental influence on microsatellite stability.
- M.Sc. candidate - GRADUATED F'09
Steve Patten, B.Sc.H. (London)
Heterogeneity of VEGFR2 in tumor vasculature: Implications for anti-angiogenic therapeutic treatments.
- M.Sc. candidate - GRADUATED F'08
Mackenzie Smith, B.Sc. (Guelph)
Heterogeneity of tumor microcirculation in mammary carcinoma at different stages of tumor progression.
- M.Sc. candidate - GRADUATED W'09
Selected References
Angiogenesis and Anti-angiogenic Therapy in Cancer
- Smith MJ, Berger RW, Minhas K, Moorehead RA, Coomber BL. Heterogeneity of vascular and progenitor cell compartments in tumours from MMTV-PyVmT transgenic mice during mammary cancer progression. Int J Exp Pathol. 2011 Apr;92(2):106-16.
- Patten SG, Adamcic U, Lacombe K, Minhas K, Skowronski K, Coomber BL. VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment. BMC Cancer. 2010 Dec 15;10:683.
- Fathers KE, Stone CM, Minhas K, Marriott JJ, Greenwood JD, Dumond DJ, Coomber BL. Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. Am J Pathol. 2005, 167(6): 1753-62.
Tumour Biology, Microenvironment and Mutagenesis
- Shahrzad S, Lacombe K, Adamcic U, Minhas K, Coomber BL. Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia. Cancer Lett. 2010 Nov 1;297(1):75-83.
- Shahrzad S, Shirasawa S, Sasazuki T, Rak JW, Coomber BL. Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts. Oncogene 2008, 27(26): 3729-38.
- Shahrzad S, Quayle L, Stone C, Plumb C, Shirasawa S, Rak JW, Coomber BL. Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulations of MSH2 expression. Cancer Res. 2005, 65(18): 8134-41.
- Yu JL, Rak JW, Coomber BL, Hicklin, D, Kerbel RS. 2002 Disruption of p53 decreases tumor susceptibility to anti-angiogenic therapy. Science, 295:1526-1528.
Epigenetic Changes in Cancer
- Skowronski K, Dubey S, Rodenhiser D, Coomber B. Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. Epigenetics. 2010 Aug 16;5(6):547-56.
- Shahrzad S, Bertrand K, Minhas K, Coomber BL. Induction of DNA hypomethylation by tumor hypoxia. Epigenetics 2007, 2(2):119-125.
Cancer Cell Survival in Suspension
- Adham SA, Sher I, Coomber BL. Molecular blockade of VEGFR2 in human epithelial ovarian carcinoma cells. Lab Invest. 2010, 90(5):709-23.
- Plumb CL, Adamcic U, Shahrzad S, Minhas K, Adham SA, Coomber BL. Modulation of the tumor suppressor protein alpha-catenin by ischemic microenvironment. Am J Pathol. 2009 Oct;175(4):1662-74.
- Sher I, Adham SA, Petrik J, Coomber BL. Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis. Int J Cancer 2009, 124(3):553-61.
