Contact Information
Extension: 54939 | Email: bkalisch@ovc.uoguelph.ca
Areas of Interest
The primary focus of our research program is to elucidate and compare the mechanisms involved in the regulation of expression of genes that are important in cholinergic neuron function and Alzheimer Disease.
Specifically, we are investigating nerve growth factor signal transduction pathways and the role of nitric oxide in the regulation of expression of cholinergic genes, amyloid precursor protein, tau, low density lipoprotein receptor-related protein and apolipoprotein E. The effects of oxidative stress on the regulation of expression of these genes is also being investigated.
Graduate Students
Kate Reilly, B.Sc.H. (Guelph)
- MBS candidate
Abrar Softah, B.Sc. (Saudi Arabia)
Effects of cocaine on mu-opioid receptor expression.
- M.Sc. candidate
Megan Whaley,
B.Sc.H. (Guelph)
The Effects of Nerve Growth Factor on GPER Expression and the influence of GPER on Apo E Expression in Response to Estrogens.
- MBS candidate
Farwa Batool, B.Sc. (Waterloo)
Effects of NGF on secretase expression.
- M.Sc. candidate - GRADUATED S'09
Sue Cartier, B.Sc. (Waterloo)
Regulation of amyloid protein metabolism, and effect of beta-amyloid on nerve growth factor retrograde transport.
- M.Sc. candidate GRADUATED S'08
Cheryl Cragg, B.Sc., B.A. (Guelph)
NGF-mediated regulation of tau expression in human neuroblastoma cells.
- M.Sc. candidate - GRADUATED S'09
Carlos Flores, B.Sc. (Guelph)
The effects of Nerve Growth Factor (NGF) and oxidative stress (ER Stress) on ATF3 levels.
- M.Sc. candidate, BMED+TOX - GRADUATED F'08
Beau Frigault, B.Sc.H. (Guelph)
The Cloning of ADAM10 and BACE1 promoter regions and the effect of NGF on these regions.
- M.Sc. candidate - GRADUATED S'10
Tomas Grana, B.Sc. (Guelph)
NGF-mediated regulation of low density lipoprotein-related protein in a cholinergic neuronal model.
- M.Sc. candidate - GRADUATED F'08
Simon Lui, B.Sc.H. (Guelph)
NGF-mediated regulation of nitric oxide synthase in PC12 cells.
- MBS candidate - GRADUATED S'11
Rachel Mixer, B.Sc. (Guelph)
Environmental conditions affecting the expression of NOS in PC12 cells.
- M.Sc. candidate - GRADUATED S'09
Vishal Patel, B.Sc. (Guelph)
The role of ATF3 in amyloid precursor protein expression and processing.
- M.Sc. candidate - GRADUATED F'08
Warren Winick, B.Sc.H. (Guelph)
Nitric Oxide and Histone Deacetylases Modulate Cocaine-Induced Mu-Opioid Receptor Levels in PC12 Cells.
- MBS candidate - GRADUATED W'12
Selected References
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MacKinnon, J.C., Huether, P. and Kalisch, B.E. (2012) Effects of nerve growth factor and nitric oxide synthase inhibitors on amyloid precursor protein mRNA levels and protein stability. Open Biochem. J. In Press
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Kalisch, B.E., Baskey, J.C. and Rylett, R.J. (2012) The relationship between choline acetyltransferase and nitric oxide synthase isoform expression in Alzheimer’s disease. J. Alzheimers Dis. 2:105. doi:10.4172/2161-0460.1000105
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Cragg, C.L., MacKinnon, J.C. and Kalisch, B.E. (2012) Nitric oxide synthase inhibitors modulate nerve-growth-factor mediated activation of Akt. ISRN Cell Biology, vol. 2012, Article ID 847974, doi:10.5402/2012/847974.
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Binnington, J.C. and Kalisch, B.E. (2007) Nitric oxide synthase inhibitors modulate nerve growth factor-mediated regulation of amyloid precursor protein expression in PC12 cells. J. Neurochem. 101: 422-433.
