Contact Information
Extension: 54948 | Email: gkirby@ovc.uoguelph.ca
Areas of Interest
- Molecular diagnostics and early biomarkers of disease
- Regulation of expression of drug metabolizing enzymes
- Functional significance of altered expression of drug metabolizing enzymes during cellular injury
Current Graduate Students
Humaira Adnan, D.V.M. (Pakistan), M.Sc.H. (Pakistan)
Role of glutathione S-transferase A1 in stress cell signaling.
- Ph.D. candidate
Ryan Campbell, B.Sc.H. (York)
- MBS candidate
Elyse Hargreaves, B.Sc.H. (Guelph)
- MBS candidate
Sangsoo (Daniel) Kim, B.Sc. (Waterloo)
Role of cytochrome P450 2A5 bilirubin metabolism and protection against bilirubin toxicity.
- M.Sc. candidate
Larry Morgan, B.Sc. (Guelph)
- M.Sc. candidate
Kevin Binsell, B.Sc. (Erie, PA)
- M.Sc. candidate - GRADUATED F'08
Meghan Larin, B.Sc. (Waterloo)
Transcriptional Regulation of Murine Cytochrome P450 2A5 by Glucocorticoids: Implications For Nicotine Metabolism
- M.Sc. candidate - GRADUATED S'09
Kimberly MacIntosh, B.Sc. (Guelph)
Post-transcriptional regulation of Murine Cytochrome P450 2A5 by Heme.
- MBS candidate - GRADUATED S'11
Hridya Mondal, B.S. (CUNY)
Development and validation of a method to determine CYP2A6 activity by measuring cotinine and trans-3′-hydroxycotinine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- MBS candidate - GRADUATED F'11
Kathleen Nichols, B.Sc. (Guelph)
Regulation of Cytochrome P450 2A5 During Hepatic Injury.
- Ph.D. candidate - GRADUATED S'09
Kelly O'Rourke, B.ScH. (Guelph)
Role of glutathione S-transferase AI in c-Jun N-terminal kinase inhibition, cellular proliferation and differentiation.
- M.Sc. candidate - GRADUATED W'10
Selected References
- Onica T, Nichols K, Larin M, Maslen A, Dvorak Z, Pascussi JF, Ng L, Vilarem MJ, Maurel P and Kirby GM (2008). Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increase3d binding of hepatic nuclear factor 4alpha to the proximal promotor. Molecular Pharmacology Feb;73(2): 451-460.
- Nichols K and Kirby GM (2008) Microarray analysis of hepatic gene expression in Pyrazole-mediated hepatotoxicity: identification of potential stimuli of Cyp2a5 induction. Biochemical Pharmacology 38: 538-551.
- Nichols KD and Kirby GM (2008). Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress. Biochemical Pharmacology 75: 1230-1239.
- Hobson DJ, Rupa P, Diaz GJ, Zhang H, Yang M, Mine Y, Turner PV and Kirby GM (2007) Proteomic analysis of ovomucoid hypersensitivity in mice by two-dimensional difference gel electrophoresis (2D-DIGE). Food Chem Toxicol 45: 2372-2380.
- Ng L, Nichols K, O'Rourke K, Maslen A, Kirby GM (2007) Repression of human GSTA1 by interleukin-1beta is mediated by variant hepatic nuclear factor 1-C. Mol Pharmacol [Jan;71(1): 201-8].
- Romero L, Andrews K, Ng L, O'Rourke K, Maslen A, Kirby G (2006) Human GST A1-1 reduces c-Jun N-terminal kinase signaling and apoptosis in Caco-2 cells. Biochem J 400(1): 135-141.
- Romero L, Ng L, and Kirby GM (2006) Chemical inducers of rodent glutathione S-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C. Mol Pharmacol. 70(1): 277-86.
- Gilmore WJ, and Kirby GM (2004) Influence of endoplasmic reticulum stress on murine hepatic Cyp2a5 expression. J Pharmacol Exp Ther. 308: 600-608.
- Gilmore WJ, Hartmann G, Piquette-Miller M, Marriot J, and Kirby GM (2003) Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression. Toxicology 184:211-226.
- Barker HJ, Alpert LC, Compton CC, Maslen A, and Kirby GM (2002). Loss of glutathione S-transferase (GST) m phenotype in colorectal adenocarcinomas from patients with a GSTM1 positive genotype. Cancer Letters 177: 65-74.
- Romero L, Higgins MA, Barker HJ, Boudreau K, Maslen A, Gilmore J, and Kirby GM (2002) Down-regulation of alpha class glutathione S-transferase expression by interleukin-1 beta in human intestinal epithelial cells (Caco-2) in culture. Drug Metabolism and Disposition 30;1-8.
