W. Glen Pyle

(BSc Guelph, PhD Tennessee | Associate Professor)

Contact Information

Extension: 54772 | Email: gpyle@uoguelph.ca

Lab Website: www.uoguelph.ca/~gpyle/

Areas of Interest

  • cardiac muscle mechanics and intracellular signaling control of muscle function by Z-disc proteins
  • role of Z-disc proteins in the development of heart failure
  • the role of the hormone Relaxin in heart failuure
  • control of heart muscle contractility by oestrogen and testosterone

Current Graduate Students

Afrah Al-Najeer, B.V.Sc. (Iraq), M.Sc. (Iraq)
Effects of endothelin in integrated venous function in health and disease.
- Ph.D. candidate

Elizabeth Sinclair, B.Sc.H (Guelph), DVM (Guelph)
Physiochemical characterization of canine heart failure.
- Ph.D. candidate



Justyna Kulpa, B.M.Sc. (Western)
Effect of estrogen receptor activation on cardiac myofilaments.
- M.Sc. candidate - GRADUATED S'10

Lija Gaikis, B.A.H. (Wilfrid Laurier)
Myofilament Analysis and Echocardiographic Assessment of CapZ Deficient Mice in Response to Cardiac Stress.
- MBS candidate - GRADUATED W'11

Chris Schmidt, B.A. (Toronto), B.Sc. (Guelph)
Cardiotoxicity of Doxorubicin
- M.Sc. candidate - GRADUATED W'09

Feng Hua Yang, B.Sc. (China), C.M.Sc. (Guelph)
cCapZ as a therapeutic target in heart failure.
- Ph.D. candidate - GRADUATED W'12

 

Selected References

  • Shaw EE, Wood P, Kulpa J, Yang FH, Summerlee AJ, Pyle WG. Relaxin alters cardiac myofilament function through a PKC-dependent pathway. Am J Physiol Heart Circ Physiol. 2009 May 8. [Epub ahead of print].
  • Yang F, Aiello DL, Pyle WG. Cardiac myofilament regulation by protein phosphatase type 1alpha and CapZ. Biochem Cell Biol 2008 Feb;86(1):70-8.
  • Pyle WG, Solaro RJ. At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res 2004; 94: 296-305.
  • Pyle WG. Searching for the missing link: a role for the actin capping protein in heart failure. Can J Cardiol 2004; 20: 1429-32.
  • Pyle WG, Hart MC, Cooper JA, Sumandea MP, De Tombe PP, Solaro RJ. Actin capping protein: an essential element in protein kinase signaling to the myofilaments. Circ. Res. 2002; 90: 1299-1306.
  • Pyle WG, Sumandea MP, Solaro RJ, De Tombe PP. Troponin I serines 43/45 and regulation of cardiac myofilament function. Am. J. Physiol. Heart Circ. Physiol. 2002; 283: H1215-H1224.