Contact Information
Extension: 54935 | Email: jlamarre@uoguelph.ca
Areas of Interest
- Regulation of gene expression, growth and angiogenesis in normal and cancerous liver.
One aspect of the research program in my laboratory is focussed on understanding the mechanisms behind the regulation of gene expression during the growth of normal and neoplastic liver cells. In particular, we are interested in understanding how transcriptional and post-transcriptional processes that regulate the levels of mRNA in the cell ultimately control cellular growth and the recruitment of capillaries into the tissue (angiogenesis). Using current techniques in molecular biology and proteomics, we aim to identify factors which act at the transcriptional and post-transcriptional levels to regulate these processes. These studies have particular relevance to common diseases of the liver such as primary and metastatic neoplasia and cirrhosis. - Regulation of mRNA stability in ovarian follicles.
The other major component of our research program involves the investigation of post-transcriptional changes in the stability of mRNA in the mammalian ovary. In this program, we seek to understand how signalling processes initiated by hormones ultimately result in rapid changes in the level of cellular mRNAs by changing the rate at which they are degraded. These studies are highly relevant to understanding fertility in domestic animals and humans.
Current Graduate Students
David Balogh, B.Sc.H. (Guelph)
- MBS candidate
Midori Buechli, B.Sc. (Laurentian)
- M.Sc. candidate
Tara Richards, B.Sc. (Waterloo), D.V.M. (Guelph)
Cytokines involved in modulating canine intraocular inflammation and corneal wound healing.
- Ph.D. candidate
Negin Sardashti, B.Sc. (Waterloo)
- MBS candidate
Meghan Brighten, B.Sc. (Guelph)
Role of mRNA stability to invasive ovarian cancer cells.
- M.Sc. candidate - GRADUATED, F'08
Mahmood El-sweisi, B.Sc. (Waterloo)
- M.Sc. candidate - GRADUATED S'10
Bob McGray, B.Sc. (Guelph)
The role of insulin like growth factor 1 (IGF-1) in the regulation of thrombospondin-1 (TSP-1) mRNA stability in the developing ovarian follicle.
- M.Sc. candidate GRADUATED W'08
Tim Gingerich, B.A.Sc. (Guelph), B.Sc. (Guelph)
Regulation of mRNA stability by AU-rich element binding proteins.
- Ph.D. candidate - GRADUATED F'10
Shannon Lees, B.Sc. (Guelph)
Shuttling of AU Binding Proteins in Ovarian Granulosa Cells.
- M.Sc. candidate - GRADUATED S'09
Abimbola Onayemi, B.Sc. (McGill)
TGFB dependent effects on HuR and TTP expression in ovarian granulosa cells.
- M.Sc. candidate - GRADUATED S'10
Raji Sextus, B.Sc. (York)
RNA binding protein expression during early embryonic development.
- M.Sc. candidate - GRADUATED S'10
Sareekha Singh, B.A.H. (Toronto)
IGF-IR dependent regulation of RNA binding proteins in a breast cancer model.
- M.Sc. candidate - GRADUATED S'10
Divya Viswanathan, B.Sc. (Guelph)
mRNA stability of the aromatase gene and its role in fertility.
- M.Sc. candidate - GRADUATED F'08
Selected References
- McGray, AJR, Gingerich T, Petrik JJ, LaMarre J. Rapid Insulin-like Growth Factor-1-induced Changes in Granulosa Cell Thrombospondin-1 Expression In Vitro. Journal of Reproduction and Development, Vol. 57, No. 1, 2011. In Press.
- McGray, AJR, Gingerich T, Petrik JJ, LaMarre J. Regulation of Thrombospondin-1 expression through AU-rich elements in the 3'UTR of the mRNA. Cell Mol Biol Lett. 2010 Dec 15. [Epub ahead of print]
- LaMarre J, Maclusky NJ. Regulated messenger ribonucleic Acid stability: a key actor in the complex play of hormonal control. Endocrinology. 2010 Apr;151(4):1390.
- Greenaway J, Lawler J, Moorehead R, Bornstein P, LaMarre J, Petrik J. Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol. 2007 Mar;210(3):807-18.
- Greenaway J, Gentry PA, Feige JJ, LaMarre J, Petrik JJ. Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development. Biol Reprod. 2005 May;72(5):1071-8.
