John F. Leatherland

(BSc Sheffield, PhD Leeds, DSc Sheffield | University Professor Emeritus)

Contact Information

Extension: 54904 | Email: jleather@uoguelph.ca

Areas of Interest

Hormonal control of early development of fishes.

  • Environmental factors affecting early development of fish.
  • Role of environmental endocrine mimics on early development of fish.
  • Endocrine regulation of growth and energy partitioning in fish.
  • Gonadal steroidogenesis of fish.

Graduate Students

 

Jacqueline Ferris, B.Sc., BPHE (Queen's)
Effects of in ovo exposure of rainbow trout to glucocorticoid (GR) and estrogen receptor (ER) agonists and antagonists on ER and GR gene expression and vertebral morphology.
- M.Sc. candidate - GRADUATED S'11

Mao Li, M.Sc. (Guelph)
The actions of cortisol on rainbown trout (Oncorhyncus mykiss) early embryo developmental biology.
- Ph.D. candidate - GRADUATED W'11

Selected References (2000 - present)

Publications in Refereed Journals

  • Li, M., Bureau, D., King, W.A., Leatherland, J.F. 2010. The actions of in ovo cortisol on egg fertility, embryo development and the expression of growth-related genes in rainbow trout embryos, and the growth performance of juveniles. Molecular, Reproduction and Development 77: 922-931. Doi: 10.1002/mrd. 21239.
  • Leatherland, J.F., Li, M., Barkataki, S. 2010. Stressors, glucocorticoids and ovarian function in teleosts. Journal of Fish Biology 76: 86-111.
  • Aluru, N., Leatherland, J.F., Vijayan, M.M. 2010. Bisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trout. PLoS One 5(5): e10741. doi: 10.1371.
  • Raine, J.C., Leatherland, J.F. 2008.  Distribution of immunoreactive thyroxine in the endostyle and thyroid tissue of the sea lamprey Petromyzon marinus L., 1758.  Journal of Fish Biology 72: 1-9.
  • Li, M., Leatherland, J.F. 2008.  Temperature and ration effects on components of the IGF system and growth performance of rainbow trout (Oncorhynchus mykiss) during the transition from late stage embryos to early stage juveniles.  General & Comparative Endocrinology 155: 668-679.
  • Cameron, C., Moccia, R., Azevedo, P., Leatherland, J.F. 2007. Effect of diet and ration on the relationship between plasma GH and IGF-1 concentrations in Arctic charr, Salvelinus alpinus (L.) Aquaculture Research 38: 877-886.
  • Li, M., Leatherland, J.F. 2007. Temperature and ration effects on components of the IGF system and growth performance of rainbow trout (Oncorhynchus mykiss) during the transition from late stage embryos to early stage juveniles. General and Comparative Endocrinology (In press – accepted September 2007).
  • Li, M., Raine, J., Leatherland, J.F. 2007. Expression profiles of growth-related genes during the very early development of rainbow trout embryos reared at two incubation temperatures. General and Comparative Endocrinology 153: 302-310.
  • Raine, J.C., Hua, K., Bureau, D.P., Vijayan, M.M., Leatherland, J.F. 2007. Influence of ration level and rearing temperature on hepatic GHR1 and 2, and hepatic and intestinal TRα and TRβ gene expression in late stages of rainbow trout embryos. Journal of Fish Biology 71: 148-162.
  • Raine, J.C., Bureau, D.P., Vijayan, M.M., Leatherland, J.F. 2007. Influence of ration and rearing temperature on hepatic GHR1 and 2 and intestinal TRα and TRβ gene expression in rainbow trout fry (late state embryos). Journal of Fish Biology 71: 148-163.
  • Li, M., Greenaway, J., Raine, J., Petrik, J., Hahnel, A., Leatherland, J. 2006. Growth hormone and insulin-like growth factor gene expression prior to the development of the pituitary gland in rainbow trout (Oncorhynchus mykiss) embryos reared at two temperatures. Comparative Biochemistry and Physiology 143: 514-522.
  • Aluru, N., Renaud, R., Leatherland, J.F., Vijayan, M.M. 2005. Ah receptor-mediated impairment of interrenal steroidogenesis involves StAR protein and P450scc gene attenuation in rainbow trout. Toxicological Sciences 84: 260-269.
  • Leatherland, J.F., Lin, L., Renaud, R. 2005. Effect of glutamate and somatostatin-14 on basal and cAMP-stimulated steroidogenesis by rainbow trout (Oncorhynchus mykiss) ovarian follicles, in vitro. Comparative Biochemistry & Physiology 140B: 647-656.
  • Petkam, R., Renaud, R., Lin, R., Boermans, H., Leatherland, J. 2005. Effects of sub-lethal levels of dichlorodiphenyltrichloroethane and dichlorodiphenyldichloroethylene on in vitro steroid biosynthesis by ovarian follicles or steroid metabolism by embryos of rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 73: 288-298.
  • Raine, J.C., Cameron, C., Vijayan, M.M., MacKenzie, D.S., Leatherland, J.F. 2005. Effect of fasting on thyroid hormone levels, and TRa and TRB mRNA accumulation in late-stage embryo and juvenile rainbow trout, Oncorhynchus mykiss. Comparative Biochemistry and Physiology 140A: 452-459.
  • Raine, J.C., Strelive, U., Leatherland, J.F. 2005. The thyroid tissue of juvenile rainbow trout, Oncorhynchus mykiss is tubular, not follicular. Journal of Fish Biology 67: 823-833.
  • Cameron, C., Moccia, R.D., Leatherland, J.F. 2004. Influence of ration level on the control of in vitro pituitary GH release in Arctic charr. General & Comparative Endocrinology 141: 93-100.
  • Leatherland, J.F., Lin, L., Renaud, R. 2004. Effect of glutamate on basal steroidogenesis by ovarian follicles of rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry & Physiology 138B: 71-80.
  • Lowartz, S., Renaud, R., Beamish, F.W.H., Leatherland, J.F. 2004. Evidence for 15 alpha- and 7 alpha- hydroxylase activity in gonadal tissue of the early-life stages of sea lampreys, Petromyzon marinus. Comparative Biochemistry & Physiology 138B: 119-127.
  • Petkam, R, Renaud, R., Freitas, A.M.M.S., Canario, A.V.M., Leatherland, J.F. 2004. In vitro metabolism of progesterone, androgens and estrogens by rainbow trout embryos. Fish Physiology & Biochemistry 27: 117-128.
  • Raine, J.C., Cameron, C., Vijayan, M.M., LaMarre, J., Leatherland, J.F. 2004. The effect of elevated oocytes triiodothyronine content on development of rainbow trout embryos and the expression of mRNA encoding for thyroid hormone receptors. Journal of Fish Biology 65: 206-226.
  • Leatherland, J.F., Ogasawara, K., Rahman, M.S., Renaud, R., Yamashiro, H., Takemura, A. 2003. In vitro steroidogenesis of the gonads of the protogynous Pacific wrasse, Haliochoeres trimaculatus. Journal of Fish Biology 62: 1414-1434.
  • Lowartz, S., Petkam, R., Renaud, R., Beamish, F.W.H., Kime, D.E., Raeside, J., Leatherland, J.F. 2003. Blood steroid profile and in vitro steroidogenesis by ovarian follicles and testis fragments of adult sea lamprey, Petromyzon marinus. Comparative Biochemistry and Physiology 134: 365-376.
  • Petkam, R., Renaud, R.L., Freitas, A.M.M.S., Canario, A.V.M., Raeside, J.I., Kime, D.E., Leatherland, J.F. 2003. In vitro metabolism of pregnenolone to 7α-hydroxypregnenolone by rainbow trout embryos. General and Comparative Endocrinology: 131: 241-249.
  • Petkam, R, Renaud, R., Leatherland, J.F. 2003. The role of CYP 1A1 in the in vitro metabolism of pregnenolone by the liver of rainbow trout embryos. Comparative Biochemistry & Physiology 135C: 277-284.
  • Raine, J.C., Leatherland, J.F. 2003. Trafficking of L-triiodothyronine between ovarian fluid and oocytes of rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology 136B: 267-274.
  • Reddy, P.K., Leatherland, J.F. 2003. Influences of photoperiod and alternate days of feeding on plasma growth hormone and thyroid hormone levels in juvenile rainbow trout. Journal of Fish Biology 63: 197-212.
  • Cameron, C., Gurure, R., Reddy, K., Moccia, R., Leatherland, J. 2002. Correlation between dietary lipid:protein ratios and plasma growth and thyroid hormone levels in juvenile Arctic charr, Salvelinus alpinus (Linnaeus). Aquaculture Research 33: 383-394.
  • Leatherland, J.F., Down, N.E. 2001. Tumours and related lesions of the endocrine system of bony and cartilaginous fishes. Fish & Fisheries 2: 59-77.
  • Leatherland, J.F., Lin, L. 2001. Melatonin effects on steroid production by rainbow trout ovarian follicles in vitro: influence of stage of follicle maturation. Biological Rhythms Research 32: 557-568.
  • Mercure, F., Holloway, A.C., Tocher, D.R., Sheridan, M.A., Van Der Kraak, G., Leatherland, J.F. 2001. Influence of plasma lipid changes in response to 17β-oestradiol stimulation on plasma growth hormone, somatostatin, and thyroid hormone levels in immature rainbow trout. Journal of Fish Biology 59: 605-615.
  • Raine, J.C., Takemura, A., Leatherland, J.F. 2001. Assessment of thyroid function in adult medaka (Oryzias latipes) and juvenile rainbow trout (Oncorhynchus mykiss) using immunostaining methods. Journal of Experimental Zoology 290: 366-378.
  • Holloway, A.C., Melroe, G.T., Ehrmann, M.M., Reddy, P.K., Sheridan, M.A., Leatherland, J.F. 2000. Effect of 17beta-estradiol on the expression of somatostatin genes in rainbow trout, Oncorhynchus mykiss. American Journal of Physiology 279: R389-R393.
  • Raine, J.C., Leatherland, J.F. 2000. Morphological and functional development of the thyroid tissue in rainbow trout (Onchorhynchus mykiss). Cell and Tissue Research 301: 235-244.

Publications in Books

  • Leatherland, J.F., Woo, P.T.K. (eds.) (2010). Fish Diseases and Disorders. Volume 2, Noninfectious Disorders. 2nd Edition C.A.B. International, Oxon.
  • Leatherland, J.F. (2010). Diagnostic assessment of non-infectious disorders. In: Fish Disease, Volume 2, Noninfectious Disorders. 2nd Edition C.A.B. International, Oxon.
  • Leatherland, J.F. (2010). Endocrine and reproductive systems, including their interaction with the immune system. In: Fish Disease. Volume 2, Noninfectious Disorders. 2nd Edition C.A.B. International, Oxon. pp. 85-143.
  • Vijayan, M.M., Aluru, N., Leatherland, J.F. (2010). Stress response and the role of cortisol. In: Fish Disease. Volume 2, Noninfectious Disorders. 2nd Edition C.A.B. International, Oxon. pp. 182-201.
  • Leatherland, J.F., Ferguson, H.W. (2006). Endocrine and reproductive systems. In: Systemic Pathology of Fish. A Text and Atlas of Normal Tissues in Teleosts and their Responses to Disease. Second Edition. Edited by H.W. Ferguson, Scotian Press, London.
  • Leatherland, J.F. (2000). Contaminant-altered function in wildlife. In: Environmental Endocrine Disruptors, An Evolutionary Perspective. Edited by L. J. Guillette Jr. and D.A. Crain, Taylor and Francis, N.Y. pp. 155-216.
  • Leatherland, J.F., Woo, P.T.K. (eds.) (1998). Fish Disease. Volume III, Noninfectious Disorders. C.A.B. International, Oxon.
  • Reddy, P. K. and Leatherland, J.F. (1998). Stress Physiology. In: Fish Disease. Volume III, Noninfectious Disorders. C.A.B. International, Oxon. pp. 279-302.
  • Leatherland, J.F., Ballantyne, J. S. and Van Der Kraak, G. (1998). Diagnostic assessment of noninfectious disorders of fish: new approaches to considerations of metabolic dysfunction. In: Fish Disease. Volume III, Noninfectious Disorders. C.A.B. International, Oxon. pp. 335-366.