James John Petrik

(M.Sc., Ph.D. Western | Professor)

JPetrik

Contact Information

Extension: 54921 | Email: jpetrik@uoguelph.ca

Areas of Interest

  • The etiology and biology of ovarian cancer
  • The regulation of angiogenesis
  • Roles of growth factors and cytokines in mediating cellular events associated with ovarian follicular development
  • Etiology and cellular biology of reproductive disorders

Current Graduate Students

Lisa Kellenberger, B.Sc.H. (Queen's)
The relationship between dysglycemia and ovarian cancer.
- Ph.D. candidate

Amanda Kerr, B.Sc.H. (Guelph)
The effects of chronic systemic inflammation on the progression of epithelial ovarian cancer (EOC).
- M.Sc. candidate

Samantha Russell, B.Sc.H. (Guelph)
- M.Sc. candidate

 

Alanna Chaudhry, B.Sc. (McMaster), M.Sc. (McMaster)
An analysis of equine hoof keratinocytes in vitro.
- Ph.D. candidate - GRADUATED W'10

Krystin Logan, B.Sc.(Guelph)
Vascular endothelial growth factor as a cell survival factor in human ovarian cancer cell lines.
- M.Sc. candidate - GRADUATED F'08

Nicole Solinger, B.Sc. (Guelph)
The role of thrombospondin-1 (TSP-1) in epithelial ovarian cancer (EOC) and its potential use as a therapeutic target.
- Ph.D. candidate - GRADUATED, W'12

Selected References

  • Campbell NE, Kellenberger LD, Greenaway J, Linnerth-Petrik N, Moorehead RA, Petrik J. Extracellular matrix proteins and tumor angiogenesis. J Oncol. Epub ahead of print. 586905, June, 2010.

  • Campbell NE, Greenaway J, Henkin J, Moorehead RA, Petrik J. The thrombospondin-1 mimetic ABT-510 increases the uptake and effectiveness of cisplatin and paclitaxel in a mouse model of epithelial ovarian cancer. Neoplasia. 12: 275-283, 2010.

  • Kellenberger LD, Bruin JE, Greenaway J, Campbell N, Moorehead RA, Holloway AC, Petrik J. The role of dysregulated glucose metabolism in epithelial ovarian cancer. J Oncol. Epub ahead of print. 514310, Jan 2010.

  • Bruin JE, Petrik JJ, Hyslop JR, Raha S, Tarnopolsky MA, Gerstein HC, Holloway AC. Rosiglitazone improves pancreatic mitochondrial function in an animal model of dysglycemia:  role of the insulin-like growth factor axis. Endocrine. 37: 303-311, 2010.

  • Linnerth NM, Siwicky MD, Campbell CI, Watson KL, Petrik JJ, Whitsett JA, Moorehead RA. Type I insulin-like growth factor receptor induces pulmonary tumourigenesis. Neoplasia. 11: 672-682, 2009.

  • PetrikJ, Gerstein HC, Cesta CE, Kellenberger LD, Alfaidy N, Holloway AC. Effects of rosiglitazone on ovarian function and fertility in animals with reduced fertility following fetal and neonatal exposure to nicotine. Endocrine. 36: 281-290, 2009.

  • Jones RA, Campbell CI, Wood GA, Petrik JJ, Moorehead RA. Reversibility and recurrence of IGF-IR-induced mammary tumors. Oncogene. 28: 2152-2162, 2009.

  • Linnerth NM, Greenaway JB, Petrik JJ, Moorehead RA. cAMP response element-binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation. Int J Gynecol Cancer. 2008 Nov-Dec;18(6):1248-57.

  • Greenaway J, Henkin J Moorehead R, Lawler J, Petrik J. ABT-510 induces tumour cell apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer.  Mol Cancer Ther.  8: 64-74, 2009.

  • Sher I, Adham SA, Petrik J, Coomber BL. Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis. Int J Cancer. 124: 553-561, 2008.

  • Jones RA, Campbell CI, Petrik J, Moorehead R. Characterization of a novel primary mammary tumor cell line reveals that cyclin D1 is regulated by IGF-IR. Mol Cancer Research. 6: 819-828 2008.

  • Liu X, Hart EJ, Petrik J, Nykamp SG, Bartlewski PM. Relationships between ultrasonographic image attributes, histomorphology and proliferating cell nuclear antigen expression of bovine antral follicles and corpora lutea ex situ. Reprod Domest Anim. 4 : 27-34, 2008.

  • Greenaway J, Moorehead R, Shaw P, Petrik J. Epithelial-stromal interaction increases cell proliferation, survival and tumourigenicity in a mouse model of human epithelial ovarian cancer. Gynecol Oncol. 108: 385-394, 2008.

  • Linnerth N, Greenaway J, Petrik J, Moorehead RA. CREB is Expressed at High Levels in Human Ovarian Adenocarcinoma and Regulates Ovarian Tumor Cell Proliferation. Int J Gynecol Cancer. Nov 1 Epub ahead of print, 2008.

  • Holloway AC, Petrik JJ, Bruin JE, Gerstein HC. Rosiglitazone prevents diabetes by increasing beta cell mass in an animal model of type 2 diabetes characterized by reduced beta-cell mass at birth. Diabetes Obes Metab. 10:763-771, 2008.

  • Liu X, Hart EJ, Petrik JJ, Nykamp SG, Bartlewski PM. Relationships between ultrasonographic image attributes, histomorphology and proliferating cell nuclear antigen expression of bovine antral follicles and corpora lutea ex situ. Reprod Dom Anim. 43: 27-34, 2008.

  • Holloway AC, Petrik JJ, Younglai EV. Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells. Reprod Toxicol. 24: 359-364, 2007.

  • Holloway AC, Kellenberger LD, Petrik J. Fetal and neonatal exposure to nicotine disrupts ovarian function and fertility in adult female rats. Endocrine. 30: 213-216, 2007.

  • Greenaway J, Moorehead R, P. Bornstein, J. Lawler, J. LaMarre, J. Petrik. TSP-1 directly inhibits VEGF expression in the ovary through binding and internalization through the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol. 210: 807-818, 2007.

  • Jones RA, Campbell CI, Gunther EJ, Chodosh LA, Petrik JJ, Khokha R, Moorehead R. Transgenic Overexpression of IGF-IR Disrupts Mammary Ductal Morphogenesis and Induces Tumor Formations Oncogene. 26: 1636-1644, 2007.

  • Li M, Greenaway J, Raine J, Petrik J, Hahnel A, Leatherland J. Growth hormone and insulin-like growth factor gene expression prior to the development of the pituitary gland in rainbow trout (Oncorhynchus mykiss) embryos reared at two temperatures. Compar. Biochem. Physiol. 143: 514-522, 2006.

  • Holloway, A.C., Lim, G.E., Petrik, J.J., Foster, W.G., Morrison, K.M., and Gerstein, H.C.  Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta-cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes.  Diabetologia 48: 2661-2666, 2005.

  • Betts DH, Perrault SD, Petrik J, Lin L, Favetta LA, Keefer CL, King WA. Telomere length analysis in goat clones and their offspring.  Molecular Reproduction and Development. 72: 461-470, 2005.

  • Gao YJ, Holloway AC, Zeng ZH, Lim GE, Petrik JJ, Foster WG, Lee RM. Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function. Obes Res. 13: 687-92, 2005.

  • Greenaway J, Gentry PA, Feige J-J, LaMarre J, Petrik J. Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development.  Biology of Reproduction. 72: 1071-1078, 2005.

  • Lim GE, Stals SI, Petrik JJ, Foster WG, Holloway AC. The Effects of In Utero and Lactational Exposure to Chloroform on Postnatal Growth and Glucose Tolerance in Male Wistar Rats. Endocrine. 25: 223-228, 2004.

  • Craig J, Zhu H, Dyce PW, Petrik J, Li J. Leptin enhances oocyte nuclear and cytoplasmic maturation via the MAP kinase pathway. Endocrinology. 145: 5355-63, 2004.

  • Greenaway J, Connor K, Pedersen HG, Coomber BL, LaMarre J, Petrik J. VEGF and its Receptor, Flk-1/KDR are Cytoprotective in the Extravascular Compartment of the Ovarian Follicle. Endocrinology. 145: 2896-2905, 2004