Contact Information
Extension: 54950 | Email: rmoorehe@uoguelph.ca
Areas of Interest
- Role of insulin-like growth factors in mammary and lung physiology and tumorigenesis
- Generation of transgenic mouse models to study human disease
- Signal transduction pathways and gene expression
Current Graduate Students
Sarah Elizabeth Franks, B.Sc. (Guelph)
The role of type I insulin-like growth factor receptor in lung tumorigenesis.
- Ph.D. candidate
Erinne Barnett, B.Sc.H. (Western)
The Role of MicroRNAs in Mammary Tumorigenesis.
- M.Sc. candidate - GRADUATED S'11
Craig Campbell, B.Sc. (Guelph)
Interaction between IGF-IR and ErbB2 in mammary tumorigenesis.
- Ph.D. candidiate - GRADUATED W'11
Sara Gagnon, B.Sc. (Guelph)
The influence of Akt in IGF-IR overexpressing transgenic mice.
- M.Sc. candidate - GRADUATED S'10
Rob Jones, B.Sc. (Guelph)
A transgenic mouse model to investigate the role of the type-I IGF receptor in breast cancer.
- Ph.D. candidate - GRADUATED F'08
Nicolle Linnerth, B.Sc. (Guelph)
Inducible transgenic mouse model for human lung cancer.
- Ph.D. candidate - GRADUATED F'08
Brianna Ryman, B.Sc. (Guelph)
Investigating the expression of genes and proteins involved in regulating podocyte morphology in mouse models deficient in Nck signalling.
- MBS candidate - GRADUATED S'11
Megan Siwicky, B.Sc. (Guelph)
Susceptibility of lung tumorigenesis in IGF-IR overexpressing transgenic mice.
- M.Sc. candidate - GRADUATED S'09
Devan Thompson, B.Sc. (Guelph)
The role of osteopontin in IGF-IR overexpressing transgenic mice.
- M.Sc. candidate - GRADUATED S'10
Selected References
- Linnerth, N.M., Siwicky, M.D., Campbell, C.I., Watson, K.L.M., Petrik, J.J., Whitsett, J.A., and Moorehead, R.A. Type I insulin-like growth factor receptor induces pulmonary tumorigenesis.
Neoplasia. 2009 (in press)
- Jones, R.A., Campbell, C.I., Wood, G.A., Petrik, J.J., and Moorehead, R.A., Reversibility and recurrence of IGF-IR-induced mammary tumors. Oncogene. 2009 Apr 20. [Epub ahead of print]
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Greenaway, J., Henkin, J., Lawler, J., Moorehead, R., and Petrik, J. ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer. Mol Cancer Ther. 2009 Jan;8(1):64-74.
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Jones, R.A., and Moorehead, R.A. The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis. J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):407-13. Epub 2008 Nov 11. Review.
- Linnerth, N.M., Greenaway, J.B., Petrik, J.J., and Moorehead, R.A. cAMP response element-binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation. Int J Gynecol Cancer. 2008 Jun 11.
- Jones, R.A., Campbell, C.I., Petrik, J.J., and Moorehead, R.A. Characterization of a novel primary mammary tumor cell line reveals that cyclin D1 is regulated by the type I insulin-like growth factor receptor. Mol Cancer Res. 2008 May;6(5):819-28.
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Golipour, R., Myers, D., Seagroves, T., Murphy, D., Evan, G.I., Donoghue, D.J., Moorehead, R.A. and Porter, L.A. The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Res. 2008 May 15;68(10):3591-600.
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Greenaway, J., Moorehead, R., Shaw, P., and Petrik, J. Epithelial-stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer. Gynecol Oncol. 2008 Feb;108(2):385-94. Epub 2007 Nov 26.
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Greenaway, J., Lawler, J., Moorehead, R., Bornstein, P., LaMarre, J., and Petrik, J. Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol. 2007 Mar;210(3):807-18.
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Jones, R.A., Campbell, C.I., Gunther, E.J., Chodosh, L.A., Petrik, J.J., Khokha, R., and Moorehead, R.A. Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 2007 Mar 8;26(11):1636-44. Epub 2006 Sep 4.
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Linnerth, N.L., Baldwin, M., Campbell, C., Brown, M., McGowan, H., and Moorehead, R.A. IGF-II induces CREB phosphorylation and cell survival in human lung cancer cells. Oncogene 2005 Nov; 10:24(49); 7310-9.
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Linnerth, N.L., Sirbovan, K., and Moorehead, R.A. Use of a Transgenic Mouse Model to Identify Markers of Human Lung Tumors. International Journal of Cancer 114:977-982, 2005.
