Contact Information
Extension: 54910 | Email: tmartino@uoguelph.ca
Cardiovascular Research Group Website
www.uoguelph.ca/CardiovascularResearch/Tami.html
Areas of Interest
- Circadian regulation of cardiac growth and remodeling in cardiovascular disease.
- Day/night or circadian variation in physiologic and molecular processes, and it’s unique relevance to biomarker discovery and molecular diagnostics.
- State-of-the-art high throughput technologies including microarrays, mass spectrometry proteomics, and bioinformatics.
Current Graduate Students
Faisal Alibhai, B.Sc.H. (Guelph)
The critical role of circadian rhythms in the pathophysiology of myocardial infarctions.
- Ph.D. candidate
Peter Podobed, B.Sc.H. (Toronto)
Circadian orchestration of the cardiovascular proteome. A novel paradigm characterizing cardiovascular health and disease.
- Ph.D. candidate
Elena Tsimakouridze,
B.Sc.H. (Toronto)
Applications of Circadian Rhythms in Translational Medicine; Chronotherapy and Diurnal Biomarkers for Cardiovacular Disease.
- Ph.D. candidate
Nimmi Chinnappareddy
Innate circadian mechanisms benefit (Reverse) myocardial remodeling.
PostDoctoral Fellow
Michael Bennardo, B.Sc.H. (Brock), B.A. (McMaster)
Circadian regulation of early cardiac remodeling post myocardial infarction.
- M.Sc. candidate - GRADUATED S'10
Elena Tsimakouridze, B.Sc.H. (Toronto)
Diurnal Gene Rhythms as Critical Determinants of Cardiovascular Disease.A Novel Platform for Biomarker Discovery.
- reclassified to PhD, S'12
Peter Podobed, B.Sc.H. (Toronto)
Circadian Proteomics of the Heart.
-
reclassified to PhD, F'10
Selected References
- Podobed PS, Kirby GM, Martino TA. (2011). Circadian Proteomics and Its Unique Advantage for Discovery of Biomarkers of Heart Disease. IN TK Mann, RJ Flores (EDS) Proteomics, Book 1, Intech ISBN 9789533078328.
- Martino TA, Tata N, Simpson J, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. The Primary Benefits of Angiotensin-Converting Enzyme Inhibition on Cardiac Remodeling Occur During Sleep Time in Murine Pressure Overload Hypertrophy. Journal of the American College of Cardiology, 2011;57:2020-8.
- Jugdutt BI. Optimizing pharmacotherapy for limiting cardiovascular remodeling. A Matter of Timing Therapy to Match Biology. Editorial Commentary on Martino TA et al., The Primary Benefits of ACE Inhibition (see above). J Am Coll Cardiol., 2011;57:2029-30.
- MJ Sole and Martino TA (2010). Diurnal Molecular Rhythms: Unrecognized Critical Determinants of Cardiovascular Health and Disease. In T.D. Bradley and J.S. Floras (Eds.) Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. Chapter 1. Pages 1-14.
- Martino TA, Sole MJ. Molecular Time: An Often Overlooked Dimension to Cardiovascular Disease. Circulation Research, 2009;105:1047-61.
- Sole MJ, Martino TA. Diurnal Physiology: Core Principles with Application to the Pathogenesis, Prevention and Treatment of Myocardial Hypertrophy and Failure. Journal of Applied Physiology, 2009;107:1318-27
- Chalmers JA, Lin SYJ, Martino TA, Arab S, Liu Peter, Husain M, Sole MJ, Belsham DD. Diurnal Profiling of NeuroEndocrine Genes in Murine Heart and Shift in Proopriomelanocortin Gene Expression with Pressure-Overload Cardiac Hypertrophy. Journal of Molecular Endocrinology 2008; 41(3): 117-124.
- Martino TA, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ. Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters. American Journal of Physiology– Regulatory Integrative and Comparative Physiology 2008; 294(5): 1675-1683.
- Editorial Focus by Fred W. Turek on Martino TA et. al. “Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters” Am. J. Physiol. Regul. Integr. Comp. Physiol 2008; 294(5): 1672-1674.
- Martino TA, Tata N, Bjarnason GA, Straume M, Sole MJ. Diurnal Protein Expression in Blood Revealed by High Throughput Mass Spectrometry Proteomics, and Implications for Translational Medicine and Body-Time-Of-Day (BTOD). American Journal of Physiology – Regulatory Integrative and Comparative Physiology 2007; 293(3): 1430-1437.
- Martino TA, Tata N, Belsham DD, Straume M, Lee, P, Chalmers J, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ. Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease with Rescue by Resynchronization. Hypertension 2007; 49(5): 1104-1113.
- Martino T, Arab S, Straume M, Belsham DD, Tata N, Cai F, Liu P, Trivieri M, Ralph M, Sole MJ. Day/night rhythms in gene expression of the normal murine heart. Journal of Molecular Medicine 2004; 86: 256-264.
- Ayach B, Fuse K, Martino T, Liu P. Dissecting mechanisms of innate and acquired immunity in myocarditis. Current Opinion in Cardiology 2003; 18: 175-181.
- Opavsky MA, Martino T, Rabinovitch M, Richardson C, Petric M, Trinidad C, Penninger J, Liu P. The extracellular signal-regulated kinase signaling cascade is a key determinant of susceptibility to coxsackievirus B3 infection and myocarditis in mice. Journal of Clinical Investigation 2002; 109: 1561-1569.
- Martino TA, Petric M, Weingartl H, Bergelson JM, Opavsky MA, Richardson CD, Modlin JF, Finberg RW, Kain KC, Willis N, Gauntt CJ, Liu PP. The coxsackievirus-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus. Virology 2000; 271: 99-108.
- Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nature Medicine 2000; 6: 429-434.
