Assessment of body composition in dogs with cranial cruciate ligament rupture: an observational study

Objective

The objective of this research is to describe the body composition of dogs admitted to the Ontario Veterinary College Health Sciences Centre for surgical repair of the cranial cruciate ligament. Special attention will be paid to lean tissue mass, fat mass, and bone mineral content of these dogs, and how the body composition of these dogs compares to a healthy control group.

Background

Rupture of the cranial cruciate ligament (CCL) in the stifle joint of dogs is one of the most common causes of hind-end lameness. This ligament is important for stifle stability during movement. Known risk factors for rupture of this ligament in dogs include age, breed, sex and body weight, however, body composition has yet to be assessed as a potential risk factor.

This study will assess the body composition of dogs using body condition scoring, muscle condition scoring, morphometric measurements, and a dual-energy x-ray absorptiometry (DEXA) scan. The DEXA scanner is the current gold standard method to assess body composition in dogs, and will require sedation to obtain an accurate assessment of the dog's muscle, fat and bone content.

Incentives

This study will cover the cost of:

Cruciate Group:

  • Body condition score, muscle condition score, and morphometric measurement assessments
  • Costs associated with sedation and the DEXA scan

Healthy Group:

  • Physical exam, orthopedic exam, routine bloodwork (complete blood count and biochemistry) to determine health status
  • Body condition score, muscle condition score, and morphometric measurement assessments
  • Costs associated with sedation and the DEXA scan

Owners of both groups will be provided with a detailed report outlining their dog's body composition.

Inclusion / Exclusion Criteria:

Cruciate Group

Inclusion Criteria:

  • 2-12 years of age
  • Healthy based on normal history, physical examination, complete blood count, and biochemical profile (as part of pre-op procedure)
  • Confirmed diagnosis of a cruciate ligament rupture

Exclusion Criteria:

  • Hospitalization or medication administration in the last 3 months (unless directly related to cruciate ligament rupture)

Healthy Group

Inclusion Criteria:

  • 2-12 years of age
  • Healthy based on normal history, physical examination, complete blood count, and biochemical profile

Exclusion Criteria:

  • History of orthopedic problems
  • Dogs that have an abnormality noted on physical exam, or bloodwork


Researcher

Principal Investigator: Dr. Adronie Verbrugghe DVM, PhD, Dip ECVCN, Assistant Professor

Amanda Santarossa, MSc Student

Contact

Amanda Santarossa
Email: asantaro@uoguelph.ca

Vicky Sabine, PhD
Clinical Research Coordinator
Email: vsabine@uoguelph.ca; Work Cell #: 226-218-0338